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KGF/Fibroblast growth factor 7 (FGF7) plays an important role in regulating the proliferation, migration, and differentiation of cells. FGF7 is of stromal origin and produces a paracrine effect on epithelial cells. FGF7/FGFR2 promotes invasion and migration in human gastric cancer. FGF7 is specifically utilized as a paracrine factor during the process of differentiation of the epidermal layers in the regenerating scales and in particular for beta-cells differentiation.
The recombinant human KGF consists of 179 amino acids and predicts a molecular mass of 21 KDa. A DNA sequence encoding the human KGF (Cys32-Thr194) was expressed with a polyhistidine tag at the N-terminus.
Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human FGFR2b, the ED50 for this effect is typically 3-20 ng/mL.
Accession: P21781
Endotoxin < 0.1 EU/µg
Apparent Molecular Weight: 23 KDa, reducing conditions
Lyophilized from sterile 50mM Tris，250mM NaCl，pH 7.5.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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