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Integrin alpha-V & beta-3 (ITGAV/ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.
The recombinant heterodimer of human ITGAV&ITGB3 comprises 1751 (1015+736) amino acids and has a calculated molecular mass of 193.32 (112.22+81.1) KDa. A DNA sequence encoding the extracellular domain (Met1-Val992) of human ITGAV (P06756) was fused with a his tag at the C-terminus, constructed the plasmid 1; A DNA sequence encoding the extracellular domain (Met1-Asp718) of human ITGB3 (P05106) constructed the plasmid 2.
Accession: P06756 & P05106
Endotoxin < 1 EU/µg
Lyophilized from sterile PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
[5] D L Brassard, et al. Exp Cell Res. Integrin alpha(v)beta(3)-mediated activation of apoptosis
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