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Interleukin-3 (IL-3) is a pleiotropic cytokine belonging to the interleukin family. IL-3 inhibits apoptosis and promotes cell survival by targeting the anti-apoptotic bcl-2 gene family. IL-3 is also called multi-colony stimulating factor since it stimulates the development and colony formation of multiple lineages of hematopoietic cells by activating intracellular pathways such as Ras-Raf-ERK and JAK/STAT.
Measured in a cell proliferation assay using TF-1 cells, the ED50 is < 0.1 ng/ml, corresponding to a specific activity of > 1.0 × 107 units/mg.
Accession: Q6GS87
Apparent Molecular Weight: 17~30 kDa
Endotoxin < 0.2 EU/μg
Lyophilized after extensive dialysis against PBS.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
| Storage | Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
[2] A Kusumi et al. Gan To Kagaku Ryoho. [Interleukin 3 (IL-3)]
[3] S M MacDonald et al. J Immunol. Recombinant IL-3 induces histamine release from human basophils
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