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Recombinant Human IL-17F (HEK293, C-6His)

Cat. No. M21706

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human IL-17F (HEK293, C-6His) Structure
Synonym:

Interleukin-17F human

Size Price Availability Quantity
10ug USD 210 In stock
50ug USD 535 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Recombinant Human Interleukin-17F is produced by Mammalian expression system and the target gene encoding Arg31-Gln163 is expressed with a 6His tag at the C-terminus. IL-17F has been shown to stimulate the production of several other cytokines, including IL-6, IL-8, and granulocyte colony-stimulating factor. IL-17F is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.

Accession: AAH70124.1

APMol Mass: 19 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Chemical Information
Solubility (25°C) Dissolve the lyophilized protein in distilled water.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt
References

[1] Yuchao Chen, et al. Theranostics. Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8+ T-cell memory in wild-type and humanized mice

[2] Mittal Shah, et al. RMD Open. Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells

[3] Jessica E Miller, et al. Front Immunol. IL-17A Modulates Peritoneal Macrophage Recruitment and M2 Polarization in Endometriosis

[4] Lei Wang, et al. Thorax. Targeting IL-17 attenuates hypoxia-induced pulmonary hypertension through downregulation of β-catenin

[5] Jacob S Lee, et al. Immunity. Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

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Keywords: Recombinant Human IL-17F (HEK293, C-6His), Interleukin-17F human supplier, Cytokines and Growth Factors, inhibitors, activators

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