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Interleukin 12 (IL-12) is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.
Measured by its ability to induce human natural killer lymphoma NK-92 cells to secrete interferon gamma, the ED50 is ≤2ng/mL.
Protein Sequence: DNA sequence encoding human P29459-1(IL12A) & P29460-1(IL12B) heterodimer
Predicted Molecular Weight: 65kD
Endotoxin: <0.1 EU/μg
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS. It is not recommended to reconstitute to a concentration less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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