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Hepatocyte growth factor/dispersion factor (HGF/SF) is a paracrine cell growth, motility and morphogenesis factor. It belongs to the peptidase S1 family and plasminogen subfamily, and contains 4 Kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF binds to proto-oncogenic C-Met receptor and regulates cell growth, motility and morphogenesis by activating tyrosine kinase signal cascade. HGF is secreted by mesenchymal cells and is a multifunctional cytokine mainly derived from more than skin cells. Its ability to stimulate mitosis, cell motility, and stromal invasion makes it a central player in angiogenesis, tumorigenesis, and tissue regeneration.
Measured by its ability to induce IL-11 secretion by Saos‑2 human osteosarcoma cells, the ED50 for this effect is 0.3-1.5 ng/ml.
Accession# : P14210
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, pH 8.0.
| Solubility (25°C) | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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