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GSDMD (Gasdermin D) is a protein that plays a crucial role in pyroptosis, a highly inflammatory form of cell death. It acts as a pore-forming protein, creating openings in the cell membrane and triggering the release of inflammatory molecules like interleukin-1β. GSDMD is activated by various stimuli, including infections and danger signals. It is cleaved by enzymes like caspase-1, releasing its N-terminal domain (GSDMD-N). GSDMD-N then binds to the cell membrane and forms pores, leading to pyroptosis.
Recombinant Human GSDMD Protein expressed the target gene encoding Pro278-His484 with a His tag at the N-terminus.
Accession: P57764
Predicted molecular weight: 24.47 kDa
Endotoxin < 1 EU/µg
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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