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Recombinant Human Fibroblast Growth Factor-10 (FGF-10) is a mitogen mainly produced by mesenchymal stem cells in the lung. FGF-10 belongs to the heparin binding FGF family, and is also known as Keratinocyte Growth Factor-2 (KGF-2). It shares homology with KGF and receptor binding to FGFR2-IIIb. FGF-10 promotes budding and branching morphogenesis during the multi-organ development via mesenchymal-epithelial cell interactions. FGF-10 is critical for lung and limb development, and is regulated by Shh during early development. Recombinant Human FGF-10 produced in E. coli is a single, non-glycosylated polypeptide chain containing 169 amino acids.
ED50 < 20 ng/mL, measured by a cell proliferation assay using 4 MBr-5 cells, corresponding to a specific activity of > 5.0 × 104 units/mg.
Accession # O15520
Apparent Molecular Weight: ~19.3 kDa, on SDS-PAGE under reducing conditions.
Endotoxin: < 0.2 EU/μg of protein by gel clotting method
Lyophilized after extensive dialysis against PBS.
Patent. CN119639678A 2025 Mar 18.
Patent. CN119639678A
Recombinant Human FGF-10/KGF-2 (E. coli) purchased from AbMole
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml. |
| Storage | Stable for up to 6 months at lower than -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
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