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EGF is the founding member of the EGF-family of proteins. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. EGF acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor.
Measured in a cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblast cells, the ED50 for this effect is typically 0.3-1.5 ng/mL.
A DNA sequence encoding the mature soluble form of human EGF (NP_001954.2) (Asn 971-Arg 1023) was fused with the Fc region of human IgG1 at the N-terminus.
The recombinant human EGF chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 290 amino acids and has a calculated molecular mass of 33 kDa.
Lyophilized from sterile PBS, pH 7.4.
| Solubility (25°C) | Reconstitute the lyophilized powder in sterile water to prepare a stock solution of 250 μg/ml |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. |
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Products are for research use only. Not for human use. We do not sell to patients.
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