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Dipeptidyl peptidase-4 (DPP4) is a serine exopeptidase belonging to the S9B protein family. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP).
The recombinant human DPP-4 expressed the sequence encoding the extracellular domain (Asn 29-Pro 766) of the mature form of human DPPIV with the fused Fc region of human IgG1 at the N-terminus.
Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin, the specific activity is > 2000 pmoles/min/μg.
Accession: P27487
Apparent Molecular Weight: 120-130 kDa, under reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from sterile 25 mM MES, 150 mM NaCl, pH 6.5.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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