All AbMole products are for research use only, cannot be used for human consumption.
CXCR4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 plays a role in both physiological and pathological conditions and it represents a crucial target in drug development. CXCL12 is the principal CXCR4 specific ligand and that the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) is also able to bind and activate CXCR4.
Recombinant Human CXCR4 expressed the target gene encoding Met1-Ser46 with a human IgG1 Fc tag at the N-terminus.
Loaded Recombinant Human CXCR4 on Pro-A Biosensor, can bind Recombinant Human CXCL12 with an affinity constant of 8.4 uM as determined in BLI assay.
Accession: P61073
Apparent Molecular Weight: 35-45 KDa, under reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from a 0.2 μm filtered solution of 50mM Tris-HCl, 100mM Glycine, pH7.5.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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| Recombinant Human Siglec-15 Protein (HEK293, C-mFc)
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| Recombinant Human Siglec-9 Protein (HEK293, C-Fc)
Sialic acid-binding Ig-like lectin 9(Siglec 9) is expressed by peripheral blood leukocytes, and found in liver, fetal liver, bone marrow, placenta, spleen and so on. It is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It also binds to alpha-2,3- or alpha-2,6-linked sialic acid. |
| Recombinant Human Siglec-6 Protein (HEK293, C-Fc)
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| Recombinant Human SIGLEC-10 Protein (HEK293, His Tag)
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Products are for research use only. Not for human use. We do not sell to patients.
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