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Recombinant Human CRHBP (HEK293, C-6His)

Cat. No. M31298

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human CRHBP (HEK293, C-6His) Structure
Synonym:

CRFBP; CRF-Binding Protein; Corticotropin-Releasing Hormone-Binding Protein

Size Price Availability Quantity
10ug USD 200 In stock
50ug USD 505 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Corticotropin-Releasing Factor-Binding Protein (CRHBP) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. CRHBP may inactivate CRH and may prevent inappropriate pituitary-adrenal stimulation in pregnancy. Recombinant Human Corticotropin-Releasing Factor-Binding Protein is produced by Mammalian expression system and the target gene encoding Tyr25-Leu322 is expressed with a 6His tag at the C-terminus.


Accession: P24387

Apparent Molecular Weight: 37 KDa, reducing conditions

Endotoxin < 1 EU/µg

Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mm NaCl, pH 7.5.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Xiaohong Liu, et al. Gen Comp Endocrinol. Fish pituitary show an active immune response after in vitro stimulation with Vibrio bacterin

[2] E A Linton, et al. J Clin Endocrinol Metab. Corticotropin releasing hormone-binding protein (CRH-BP): plasma levels decrease during the third trimester of normal human pregnancy

[3] R J Woods, et al. J Clin Endocrinol Metab. Association of human corticotropin-releasing hormone to its binding protein in blood may trigger clearance of the complex

[4] D N Cortright, et al. Mol Cell Endocrinol. Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein

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Keywords: Recombinant Human CRHBP (HEK293, C-6His), CRFBP; CRF-Binding Protein; Corticotropin-Releasing Hormone-Binding Protein supplier, Cytokines and Growth Factors, inhibitors, activators

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