All AbMole products are for research use only, cannot be used for human consumption.
COX-2 is s component of Prostaglandin-endoperoxide synthase (PTGS). It is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. COX-2 is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. It mediates the formation of prostaglandins from arachidonate and may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
The recombinant human COX-2 consists of 597 amino acids and predicts a molecular mass of 68.5 kDa. A DNA sequence encoding the human COX-2 (Met 1-Leu 604) was fused with a polyhistidine tag at the C-terminus.
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 66 kDa, reducing conditions
Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, 10% glycerol, pH 8.0.
| Form | Lyophilized powder |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
[4] James K Gierse. Methods Mol Biol. Purification of recombinant human COX-1 and COX-2
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