All AbMole products are for research use only, cannot be used for human consumption.
Species: Homo sapiens (Human)
Predicted molecular weight: 33.46 kDa
Purity: sdS-PAGE determination was >90%
Stability and storage: use manual defrosting refrigerator to avoid repeated freeze-thaw cycles. Store at 2-8 °C for one week. Store at -20 to -80°C for 12 months from date of receipt.
Biological activity: Can activate a variety of chemokine receptors, including CCR1, CCR3, CCR4 and CCR5. A major HIV suppressor is produced by CD8+ T cells. Recombinant RANTES protein induces dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). As a natural chemotactic inhibitor, processed RANTES(3-68) is a more potent inhibitor of HIV-1 infection. The second treated RANTES(4-68), which is produced by an unknown enzyme associated with monocytes and neutrophils, showed lower chemotaxis and hiv-inhibiting activity compared to RANTES(1-68) and RANTES(3-68). It may also be an agonist of the G-protein-coupled receptor GPR75, through which activation stimulates inositol triphosphate production and calcium mobilization. Together with GPR75, it may play a role in neuronal survival by activating downstream signaling pathways involving PI3, Akt, and MAP kinases. Activation of GPR75 may also play a role in insulin secretion by islet cells.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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