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Recombinant Human Cathepsin B (CHO,His)

Cat. No. M11252

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human Cathepsin B (CHO,His) Structure
Synonym:

Cathepsin B; APP secretase; APPS

Size Price Availability Quantity
10ug USD 335 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Species: Human
Purity: SDS-PAGE, > 95%
Endotoxin level: protein < 0.2 EU/μg by gel coagulation
Apparent molecular weight: ~43 kDa, sdS-PAGE under reduction conditions
Storage and stability: After receiving, the product remains stable at -20°C or below for 6 months and at 4°C for 1-2 weeks. For long-term storage, store at -70°C or below. Avoid repeated freeze-thaw cycles

Biological activity: Elevated cathepsin B levels occur in a variety of diseases, causing a variety of pathological changes, including cell death, inflammation, and toxic peptide production. For example, neuroscience studies have shown that cathepsin B plays a role in inducing epilepsy, leading to mass cell death. Epileptic seizure induced rats treated with cathepsin B inhibitors showed improved neural score and learning ability, and reduced neuronal cell death.

Chemical Information
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Annette V Jacobsen, et al. Cell Death Dis. The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

[2] Joseph Carver, et al. PLoS One. A high-throughput assay for small molecule destabilizers of the KRAS oncoprotein

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Keywords: Recombinant Human Cathepsin B (CHO,His), Cathepsin B; APP secretase; APPS supplier, Cytokines and Growth Factors, inhibitors, activators

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