All AbMole products are for research use only, cannot be used for human consumption.
RBPJ Inhibitor-1 (RIN1) is a first-in-class RBPJ inhibitor that blocks the interaction between RBPJ and SHARP.RBPJ Inhibitor-1 (RIN1) inhibits the proliferation of Notch-dependent tumor cells.
| Molecular Weight | 311.31 |
| Formula | C17H14FN3O2 |
| CAS Number | 2682114-39-0 |
| Form | Solid |
| Solubility (25°C) | DMSO > 120 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Notch Products |
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| FLI-06
FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. |
| LY900009
LY900009 is a potent, first-in-class Notch inhibitor with IC50 of 0.27 nM. |
| Tangeretin
Tangeretin is a flavonoid from citrus fruit peels, and is also selected as a Notch-1 inhibitor, which plays an important role in anti-inflammatory responses and neuroprotective effects in several disease models. |
| IMR-1
IMR-1 is a first-in-class, cell-permeable inhibitor of the Notch transcription activation complex, with an IC50 of 26 μM. IMR-1 prevents Maml1 from recruiting to the Notch ternary complex (NTC) in chromatin, inhibits transcription of Notch target genes, and has antitumor activity. |
| NVS-ZP7-4
NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. |
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Products are for research use only. Not for human use. We do not sell to patients.
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