Daraxonrasib

Cat. No. M40832

All AbMole products are for research use only, cannot be used for human consumption.

Synonym:

RMC-6236; RAS-IN-2; RAS Inhibitor A122

Size	Price	Availability
1mg	USD 55	In stock
5mg	USD 140	In stock
10mg	USD 220	In stock

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Daraxonrasib (RAS-IN-2; RMC-6236) is a potent pan-KRAS inhibitor targeting activation-state KRAS for cancer-related studies.

Cell Experiment
Cell lines	FOB 1.19, MG63, HOS, HOS-MNNG, HOS-143B, Saos2, and U2OS cells
Preparation method	Cells were seeded in 96-well plates at a density of 1.0 × 104 cells per well for 24-hour treatment. The cells were treated with DMSO or various doses of daraxonrasib (3, 5, 6, 10, 15, 30, 60, or 100 nM). After treatment, the cells were incubated with MTT solution (5 mg/ml) for 1 h. The media was then replaced with DMSO. Colorimetric changes were measured at 570 nm using a microplate reader.
Concentrations	3, 5, 6, 10, 15, 30, 60, or 100 nM
Incubation time	24 h

Animal Experiment
Animal models	WT C57BL/6 mice, Batf3−/− mice, and OT-I mice
Formulation	10% DMSO, 20% polyethylene glycol 400, 10% Kolliphor HS15, and 60% water
Dosages	25 mg/kg/day
Administration	Oral gavage

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