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Ranistat (AS-3201) is an aldose reductase (AR) inhibitor. Aldose reductase is a rate-limiting enzyme that converts D-glucose to fructose by d-sorbitol. Renistat is associated with diabetic complications (cataract formation, retinopathy, neuropathy, nephropathy). Ranistat prevents sorbitol accumulation and is therefore expected to play a role in the study of diabetic neuropathy.
| Molecular Weight | 420.19 |
| Formula | C17H11BrFN3O4 |
| CAS Number | 147254-64-6 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Nick Giannoukakis. Evaluation of ranirestat for the treatment of diabetic neuropathy
[3] Vera Bril, et al. Ranirestat for the management of diabetic sensorimotor polyneuropathy
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