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Ralinepag (APD811) is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist with EC50 of 8.5 nM, 530 nM and 850 nM for human IP receptor, rat IP receptor and human DP1 receptor, respectively. Ralinepag also inhibits the ADP-induced human platelet aggregation, with an IC50 of 38 nM.
In vivo, Ralinepag (30 mg/kg; p.o.) markedly reduces the monocrotaline (MCT)-induced increase in pulmonary arterial pressure and pulmonary vessel wall thickness in rats.
| Molecular Weight | 431.91 |
| Formula | C23H26ClNO5 |
| CAS Number | 1187856-49-0 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Prostaglandin Receptor Products |
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| Terutroban
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| Latanoprost
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