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Ralaniten

Cat. No. M10960

All AbMole products are for research use only, cannot be used for human consumption.

Ralaniten Structure
Synonym:

EPI-002

Size Price Availability Quantity
5mg USD 100 In stock
10mg USD 160 In stock
25mg USD 300 In stock
50mg USD 500 In stock
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Quality Control & Documentation
Biological Activity

Ralaniten (EPI-002) is an effective and orally active androgen receptor N-terminal domain (AR-NTD) antagonist. Ralaniten inhibits AR transcriptional activity,IC50 The value is 7.4 μM. Ralanites can be used in the study of castration-resistant prostate cancer (CRPC).

Chemical Information
Molecular Weight 394.89
Formula C21H27ClO5
CAS Number 1203490-23-6
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 4°C, protect from light, dry, sealed
References

[1] Jacky K Leung, et al. Commun Biol. Pin1 inhibition improves the efficacy of ralaniten compounds that bind to the N-terminal domain of androgen receptor

[2] Carmen A Banuelos, et al. Cancers (Basel). Ralaniten Sensitizes Enzalutamide-Resistant Prostate Cancer to Ionizing Radiation in Prostate Cancer Cells that Express Androgen Receptor Splice Variants

[3] Jon K Obst, et al. ACS Pharmacol Transl Sci. Revealing Metabolic Liabilities of Ralaniten To Enhance Novel Androgen Receptor Targeted Therapies

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Keywords: Ralaniten, EPI-002 supplier, Androgen Receptor, inhibitors, activators

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