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(±)-Nornicotine 

Cat. No. M30311

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(±)-Nornicotine  Structure

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Quality Control & Documentation
Biological Activity

(±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health.

Chemical Information
Molecular Weight 148.21
Formula C9H12N2
CAS Number 5746-86-1
Form Liquid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Rabia Najme, et al. Sci Total Environ. Identification and characterization of Nornicotine degrading strain Arthrobacter sp. NOR5

[2] Huimin Deng, et al. J Sep Sci. Enantioseparation of nornicotine in tobacco by ultraperformance convergence chromatography with tandem mass spectrometry

[3] Jiguo Qiu, et al. Appl Microbiol Biotechnol. Conversion of nornicotine to 6-hydroxy-nornicotine and 6-hydroxy-myosmine by Shinella sp. strain HZN7

[4] Bin Cai, et al. J Agric Food Chem. Variable nornicotine enantiomeric composition caused by nicotine demethylase CYP82E4 in tobacco leaf

[5] Aleksandar Knezevich, et al. Nicotine Tob Res. Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans

Related Metabolite/Endogenous Metabolite Products
2'-Deoxyinosine

2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability.

Ribitol

Ribitol (Adonitol) is a crystalline pentose alcohol formed by the reduction of ribose.

Glycodeoxycholic Acid

Glycodeoxycholic Acid is an endogenous metabolite. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis.

Glycolithocholic acid

Glycolithocholic acid, an endogenous metabolite, is a glycine conjugated secondary bile acid. Glycolithocholic acid can be used to study ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH0) and primary sclerosing cholangitis (PSC).

4-Aminohippuric Acid

4-Aminohippuric acid is a typical substrate of organic anion transport systems. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow.

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Keywords: (±)-Nornicotine  supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

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