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(±)-J-113397 

Cat. No. M29333

All AbMole products are for research use only, cannot be used for human consumption.

(±)-J-113397  Structure

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Quality Control & Documentation
Biological Activity

(±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist with a Ki of 1.8 nM for cloned human ORL1. J-113397 inhibited nociceptin/orphanin FQ-stimulated GTPγS binding to CHO cells expressing ORL1 with an IC50 value of 5.3 nM. J-113397 can be used for researching the physiological roles of nociceptin/orphanin FQ.

Chemical Information
Molecular Weight 399.57
Formula C24H37N3O2
CAS Number 217461-40-0
Form Solid
Solubility (25°C) DMSO ≥ 300 mg/mL
Storage 4°C, protect from light, dry, sealed
References

[1] Raymond F Genovese, et al. Behav Pharmacol. Mitigation of adverse behavioral impact from predator exposure by the nociceptin/orphanin FQ peptide antagonist J-113397 in rats

[2] Matteo Marti, et al. J Neurosci. The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway

[3] Claudio Trapella, et al. Bioorg Med Chem. Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist

[4] D Ichikawa, et al. Neuroreport. In vitro inhibitory effects of J-113397 on nociceptin/orphanin FQ-stimulated

[5] R Bigoni, et al. Naunyn Schmiedebergs Arch Pharmacol. In vitro characterization of J-113397, a non-peptide nociceptin/orphanin FQ receptor antagonist

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  Catalog
Abmole Inhibitor Catalog




Keywords: (±)-J-113397  supplier, Opioid Receptor, inhibitors, activators

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