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1-methyltryptophan (1 MT) is currently the most widely used IDO1 inhibitor with moderate inhibitory activity. However, the two stereoisomers of 1-mt exhibit different potency :(I) d-1 MT(1) is in phase iii clinical trials as an inhibitor of the Trp -- Kyn pathway, but does not inhibit IDO1 in vitro; (ii)L-1 MT(8), as a competitive substrate inhibitor of L-tryptophan, has moderate inhibitory activity against IDO1 (hIDO1 IC50=42μM, HeLa IDO1 IC50=18.4μM).
| Molecular Weight | 218.25 |
| Formula | C12H14N2O2 |
| CAS Number | 26988-72-7 |
| Solubility (25°C) | Water：2.5 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Related IDO Products |
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| IDO-IN-2 (NLG-919 Analogue)
NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. |
| IDO5L
IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM. |
| Coptisine
Coptisine, an alkaloid isolated from Coptis, is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. |
| Coptisine chloride
Coptisine chloride is an effective and non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. Coptisine chloride is an effective H1N1 neuraminidase (NA-1) inhibitor with IC50 of 104.6 μg/mL, which can be used for influenza A virus (H1N1) infection. |
| Coptisine-Sulfate
Coptisine Sulfate is an alkaloid isolated from coptis coptidis. It is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. |
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