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Rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 signaling pathway. Rabeprazole inhibits the viability of gastric cancer cells in vitro and may serve as a novel antineoplastic agent. The pharmacokinetics of rabeprazole were described with good precision following administration of rabeprazole across a range of doses and in a range of formulations. Rabeprazole and esomeprazole were similarly effective when administered after a meal. Rabeprazole prevents the recurrence of peptic ulcers with no evidence of a major dose-response effect in subjects on low-dose aspirin therapy.
| Molecular Weight | 381.42 |
| Formula | C18H20N3NaO3S |
| CAS Number | 117976-90-6 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Proton Pump Products |
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| Omeprazole
Omeprazol is a first-in-class proton pump inhibitor (PPI) used in the treatment of dyspepsia, laryngopharyngeal reflux (LPR) and Zollinger–Ellison syndrome. |
| Dexlansoprazole
Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties. |
| Tenatoprazole
Tenatoprazole is a procompound of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. |
| Esomeprazole Sodium
Esomeprazole Sodium is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg. |
| Esomeprazole Magnesium
Esomeprazole Magnesium is a proton pump inhibitor to reduce gastric acid secretion. |
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