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RA-9

Cat. No. M8473

All AbMole products are for research use only, cannot be used for human consumption.

RA-9 Structure

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Biological Activity

RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. RA-9 directly inhibits activity of following DUB UCH-L1, UCH-L3, USP2, USP5 and USP8 deubiquitinating enzymes, which results in rapid accumulation of poly-ubiquitinated proteins leading to cell cycle checkpoint arrest and tumor cell apoptosis.

Chemical Information
Molecular Weight 365.34
Formula C19H15N3O5
CAS Number 919091-63-7
Solubility (25°C) DMSO: 2 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Donatella Treppiedi, et al. USP8 inhibitor RA-9 reduces ACTH release and cell growth in tumor corticotrophs

[2] Katie Wan Yee Yeung, et al. Current understanding of potential ecological risks of retinoic acids and their metabolites in aquatic environments

[3] Charlotte J C Edwards-Gayle, et al. Self-Assembly, Antimicrobial Activity, and Membrane Interactions of Arginine-Capped Peptide Bola-Amphiphiles

[4] Mayako Fujihara, et al. Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9

[5] Kathleen Coughlin, et al. Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses

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Keywords: RA-9 supplier, inhibitors, activators

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