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R121919 (NBI30775) is a potent small-molecule CRF1 receptor antagonist with a Ki of 2 to 5 nM for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types.
| Molecular Weight | 380.53 |
| Formula | C22H32N6 |
| CAS Number | 195055-03-9 |
| Form | Solid |
| Solubility (25°C) | Ethanol 100 mg/mL (ultrasonic) DMSO 6.2 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CRFR Products |
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Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively. |
| Antalarmin hydrochloride
Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist with a Ki of 1 nM. |
| CP-154526 hydrochloride
CP-154526 hydrochloride is a selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1) with a Ki of 2.7 nM. CP 154526 hydrochloride shows selective for CRF1 over CRF2 (Ki = >10 μM). |
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CP-376395 is a CRF1-selective antagonist. |
| CRF (bovine) TFA
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