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Mericitabine

Cat. No. M30944

All AbMole products are for research use only, cannot be used for human consumption.

Mericitabine Structure
Synonym:

RG 7128; R-7128; PSI 6130 diisobutyrate

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Quality Control & Documentation
Biological Activity

Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.

Chemical Information
Molecular Weight 399.41
Formula C18H26FN3O6
CAS Number 940908-79-2
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ya-Chi Chen, et al. Clin Pharmacol Drug Dev. Evaluation of the effect of mericitabine at projected therapeutic and supratherapeutic doses on cardiac repolarization in healthy subjects: A thorough QT/QTc study

[2] Laetitia Canini, et al. Antivir Ther. Modelling the interaction between danoprevir and mericitabine in the treatment of chronic HCV infection

[3] Jean-Michel Pawlotsky, et al. Antivir Ther. Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase

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Keywords: Mericitabine, RG 7128; R-7128; PSI 6130 diisobutyrate supplier, Anti-infection, inhibitors, activators

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