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Quinine sulfate hydrate (2:1:4) is an orally active potassium channel inhibitor that inhibits voltage pulse-induced currents in MT mSlo3 (KCa5.1) channels +100 mV with an IC50 of 169 μM.In addition, Quinine sulfate hydrate binds to PfPNP with low nanomolar affinity. In addition, Quinine sulfatehydrate binds to purine nucleoside phosphorylase (PfPNP) with low nanomolar affinity.
| Molecular Weight | 458.53 |
| Formula | C20H30N2O8S |
| CAS Number | 6119-70-6 |
| Form | Solid |
| Storage | 4°C, protect from light, sealed |
[4] Dzenan Jahic et al. Mater Sociomed. Exercise-Associated Muscle Cramp-Doubts About the Cause
[5] J K Weser et al. N Engl J Med. Drug interactions with coumarin anticoagulants. 2
| Related Potassium Channel Products |
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| ML133 hydrochloride
ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| Doxapram hydrochloride hydrate
Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| Gliquidone
Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| Pinacidil monohydrate
Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. |
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