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Quinapril hydrochloride (Accupril) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM. Quinapril hydrochloride (Accupril) used in the treatment of hypertension and congestive heart failure. Quinapril is a prodrug. Quinapril is converted to its active metabolite, quinaprilat, in the liver. Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood.
| Molecular Weight | 474.98 |
| Formula | C25H30N2O5.HCl |
| CAS Number | 82586-55-8 |
| Solubility (25°C) | Water 90 mg/mL Ethanol 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Beata Stanisz. The influence of pharmaceutical excipients on quinapril hydrochloride stability
[3] H R Kaplan, et al. Quinapril: overview of preclinical data
[4] D Canter, et al. The safety profile of quinapril: is there a difference among ACE inhibitors?
| Related ACE Products |
|---|
| Temocapril
Temocapril is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension. |
| Enalaprilat Dihydrate
Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. |
| Imidapril hydrochloride
Imidapril hydrochloride is a angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension. |
| Ramipril
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM. |
| Enalapril Maleate
Enalapril Maleate, the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. |
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