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Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.
| Molecular Weight | 383.51 |
| CAS Number | 111974-69-7 |
| Solubility (25°C) | Ethanol 90 mg/mL DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Vania Modesto-Lowe, et al. Quetiapine for primary insomnia: Consider the risks
[2] Katherine Monahan, et al. Quetiapine withdrawal: A systematic review
[3] Karen Astrid Boldingh Debernard, et al. Quetiapine is not a sleeping pill
[4] N El-Saifi, et al. Quetiapine safety in older adults: a systematic literature review
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