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QM385 is a potent sepiapterin reductase (SPR) inhibitor with IC50 of 1.49 nM. QM385 blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability. QM385 effectively inhibits the proliferation of human CD4+ T cells at low doses.
| Molecular Weight | 409.37 |
| Formula | C17H18F3N7O2 |
| CAS Number | 2093421-02-2 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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