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PZ703b 

Cat. No. M29669

All AbMole products are for research use only, cannot be used for human consumption.

PZ703b  Structure

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Quality Control & Documentation
Biological Activity

PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research.

Chemical Information
Molecular Weight 1600.43
Formula C80H102ClF3N10O11S4
CAS Number 2471970-56-4
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic and warming and heat to 60°C)
Storage -20°C, protect from light
References

[1] Yi Xu, et al. Biochem Biophys Res Commun. Mivebresib synergized with PZ703b, a novel Bcl-xl PROTAC degrader, induces apoptosis in bladder cancer cells via the mitochondrial pathway

[2] Arvind Negi, et al. Chembiochem. Strategies to Reduce the On-Target Platelet Toxicity of Bcl-xL Inhibitors: PROTACs, SNIPERs and Prodrug-Based Approaches

[3] Pratik Pal, et al. J Med Chem. Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition

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  Catalog
Abmole Inhibitor Catalog




Keywords: PZ703b  supplier, PROTAC, inhibitors, activators

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