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PZ-2891

Cat. No. M20752

All AbMole products are for research use only, cannot be used for human consumption.

PZ-2891 Structure

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Quality Control & Documentation
Biological Activity

PZ-2891 is a selective, orally active and brain-penetrant pantothenate kinase (PANK) modulator that acts as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits PANK with IC50 of 40.2 nM, 0.7 nM and 1.3 nM for hPANK1β, hPANK2, and hPANK3, respectively.

Chemical Information
Molecular Weight 349.43
Formula C20H23N5O
CAS Number 2170608-82-7
Solubility (25°C) DMSO 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Vassilena Iankova, et al. Front Neurol. Emerging Disease-Modifying Therapies in Neurodegeneration With Brain Iron Accumulation (NBIA) Disorders

[2] Lalit Kumar Sharma, et al. Nat Commun. A therapeutic approach to pantothenate kinase associated neurodegeneration

[3] Neha Thakre, et al. Insect Biochem Mol Biol. Manipulation of pantothenate kinase in Anopheles stephensi suppresses pantothenate levels with minimal impacts on mosquito fitness

[4] Raquel M Simo-Gurge, et al. Biomolecules. Activation of Anopheles stephensi Pantothenate Kinase and Coenzyme A Biosynthesis Reduces Infection with Diverse Plasmodium Species in the Mosquito Host

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Keywords: PZ-2891 supplier, inhibitors, activators

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