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Pyrilamine is a histamine H1 receptor inverse agonist, it binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling.
| Molecular Weight | 401.46 |
| Formula | C17H23N3O1.C4H4O4 |
| CAS Number | 59-33-6 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Dong-Chan Kim, et al. Pyrilamine inhibits nicotine-induced catecholamine secretion
[2] D L Greenman, et al. Chronic feeding study of pyrilamine in Fischer 344 rats
[3] D W Kelly, et al. The metabolism and elimination of pyrilamine maleate in the rat
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