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Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.
| Molecular Weight | 596.64 |
| Formula | C31H32N8O5 |
| CAS Number | 1085412-37-8 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | Powder -20°C |
[5] Michele Olivieri, et al. Cell. A Genetic Map of the Response to DNA Damage in Human Cells
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