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PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells. PX-478 causes reduced fibrosis and fewer inflammatory infiltrates in high-fat-diet mice adipose tissues.
Chinese Journal of Analytical Chemistry. 2025 Sep 10; .
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PX-478 2HCl purchased from AbMole
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Source | Oncotarget (2017). Figure 1. PX-478 |
| Method | Western blot | |
| Cell Lines | MiaPaCa2 cells | |
| Concentrations | 10, 20, 50, 100, and 200 μM | |
| Incubation Time | 6h | |
| Results | When MiaPaCa2 cells were exposed to the highest concentration of PX-478 and noscapine, HIF-1 expression levels equaled to 55% and 62% of the control value, respectively. |
| Molecular Weight | 394.12 |
| Formula | C13H20Cl4N2O3 |
| CAS Number | 685898-44-6 |
| Solubility (25°C) | DMSO 60 mg/mL Water 35 mg/mL |
| Storage | -20°C, dry, sealed |
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