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Purvalanol B is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.Purvalanol B is Selective over a range of other protein kinases (IC50 > 10,000 nM).It Shown to have antiproliferative properties, mediated by p42/p44 MAPK. Purvalanol inhibited the nuclear accumulation of p42/p44 MAPK, an event dependent on the catalytic activity of these kinases .
| Molecular Weight | 432.91 |
| Formula | C20H25ClN6O3 |
| CAS Number | 212844-54-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 37mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
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| R547
R547 is a potent and selective ATP-competitive CDK inhibitor, with Ki values of 2 nM, 3 nM and 1 nM for CDK1/cyclin B, CDK2/cyclin E and CDK4/cyclin D1, respectively. |
| JNJ-7706621
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| PD 0332991 HCL
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Products are for research use only. Not for human use. We do not sell to patients.
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