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Purfalcamine 

Cat. No. M27683

All AbMole products are for research use only, cannot be used for human consumption.

Purfalcamine  Structure

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Biological Activity

Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage.

Chemical Information
Molecular Weight 528.62
Formula C29H33FN8O
CAS Number 1038620-68-6
Form Solid
Solubility (25°C) DMSO 12.5 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gayatri R Iyer, et al. J Biol Chem. Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen 5 triggers merozoite egress

[2] Rajshekhar Y Gaji, et al. Antimicrob Agents Chemother. Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drυgs

[3] Abhisheka Bansal, et al. J Biol Chem. Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion

[4] Nobutaka Kato, et al. Nat Chem Biol. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

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Keywords: Purfalcamine  supplier, Parasite, inhibitors, activators

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