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Puerarin is a 5-HT2C receptor antagonist. Puerarin is a flavonoid derivative from the traditional oriental medicine, Ge-gen. Puerarin is a novel open-channel blocker of IK1, which may underlie the antiarrhythmic action of puerarin. Purarin has potential antioxidant activity and impairs CYP catalyzed compound metabolism. Puerarin inhibits the expression of LPS-induced iNOS, COX-2 and CRP proteins and also suppresses their mRNAs from RT-PCR experiments in RAW264.7 cells. Puerarin protected against the effects of chronic alcohol poisoning on spatial learning and memory ability primarily because of anti-inflammatory activity and regulation of the balance of Glu and GABA. Puerarin may prevent osteoporosis by exerting stimulatory effects on bone formation and the NO/cGMP pathway, which has an important role in puerarin‑induced hBMSC proliferation and osteoblastic differentiation. Early-stage renal damages can be significantly improved by puerarin, possibly via its suppression of ICAM-1 and TNF-α expression in diabetic rat kidneys.
| Cell Experiment | |
|---|---|
| Cell lines | PC12 cells |
| Preparation method | When the cells were ∼80% confluent, they were pretreated with puerarin (4, 8 and 16 μM) for 2 h followed by H2O2 (700 μM, final concentration) for another 18 h. Wortmannin (100 nM) was also added 2 h before treatment with H2O2. |
| Concentrations | 4, 8 and 16 μM |
| Incubation time | 20 h |
| Animal Experiment | |
|---|---|
| Animal models | Male BALB/c mice |
| Formulation | - |
| Dosages | 50 mg/kg |
| Administration | Orally once daily |
| Molecular Weight | 416.38 |
| Formula | C21H20O9 |
| CAS Number | 3681-99-0 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Zhou YX, et al. Phytother Res. Puerarin: a review of pharmacological effects.
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