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Pterostilbene is a naturally-occurring dimethyl ether analog of resveratrol that is abundant in blueberries. Like resveratrol, pterostilbene acts as a powerful antioxidant, suppresses the synthesis of prostaglandin E2 from lipopolysaccharide-stimulated human peripheral blood mononuclear cells (IC50 = 1.0 μM for pterostilbene, 3.2 μM for resveratrol), and inhibits cell proliferation (IC50 = ~60 μM for both compounds). Pterostilbene blocks the activation of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways, reducing NF-κB and AP-1 transcriptional activation.
| Molecular Weight | 256.3 |
| Formula | C16H16O3 |
| CAS Number | 537-42-8 |
| Form | Solid |
| Solubility (25°C) | DMSO: ≥ 16 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Elena Obrador, et al. Pterostilbene in Cancer Therapy
[2] Hyunsook Kim, et al. Chemistry of Pterostilbene and Its Metabolic Effects
[4] Pei Wang, et al. Metabolism and pharmacokinetics of resveratrol and pterostilbene
[5] Yi-Rong Li, et al. Effect of resveratrol and pterostilbene on aging and longevity
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