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PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).
Toxicol Lett. 2025 Jan;403:50-65.
Activation of Wnt/β-catenin signaling to increase B lymphoma Moloney murine leukemia virus insertion region 1 by lithium chloride attenuates the toxicity of cisplatin in the HEI-OC1 auditory cells
PTC-209 purchased from AbMole
| Molecular Weight | 495.19 |
| Formula | C17H13Br2N5OS |
| CAS Number | 315704-66-6 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Yu Kong, et al. Targeting of BMI-1 with PTC-209 inhibits glioblastoma development
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