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Pseudouridine

Cat. No. M21596

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Pseudouridine Structure
Size Price Availability Quantity
5mg USD 35 In stock
10mg USD 55 In stock
25mg USD 105 In stock
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Quality Control & Documentation
Biological Activity

Pseudouridine, an isomer of uridine, is also the most abundant modified nucleoside in non-coding RNA. Pseudouridine can fine-tune and stabilize the regional structure in rRNA and tRNA to maintain their function in mRNA decoding, ribosome assembly, processing, and translation.

Chemical Information
Molecular Weight 244.20
Formula C9H12N2O6
CAS Number 1445-07-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chen Xue, et al. Signal Transduct Target Ther. Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine

[2] Jonas Cerneckis, et al. Trends Pharmacol Sci. Decoding pseudouridine: an emerging target for therapeutic development

[3] Jennifer A Stockert, et al. Urol Oncol. Pseudouridine as a novel biomarker in prostate cancer

[4] Thomas M Carlile, et al. Nature. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells

[5] Katalin Karik, et al. Mol Ther. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability

Related Metabolite/Endogenous Metabolite Products
2'-Deoxyinosine

2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability.

Ribitol

Ribitol (Adonitol) is a crystalline pentose alcohol formed by the reduction of ribose.

Glycodeoxycholic Acid

Glycodeoxycholic Acid is an endogenous metabolite. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis.

Glycolithocholic acid

Glycolithocholic acid, an endogenous metabolite, is a glycine conjugated secondary bile acid. Glycolithocholic acid can be used to study ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH0) and primary sclerosing cholangitis (PSC).

4-Aminohippuric Acid

4-Aminohippuric acid is a typical substrate of organic anion transport systems. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow.

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Keywords: Pseudouridine supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

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