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PSB-12379

Cat. No. M11275

All AbMole products are for research use only, cannot be used for human consumption.

PSB-12379  Structure

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Quality Control & Documentation
Biological Activity

Psb-12379 is a nucleotide analogue and a potent ECTO-5 '-nucleotidase (CD73) inhibitor with Kis values of 9.03 nM (rat) and 2.21 nM (human).

Chemical Information
Molecular Weight 515.35
Formula C18H23N5O9P2
CAS Number 1802226-78-3
Solubility (25°C) Water ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gabor Viczjan, et al. Int J Mol Sci. A Body of Circumstantial Evidence for the Irreversible Ectonucleotidase Inhibitory Action of FSCPX, an Agent Known as a Selective Irreversible A 1 Adenosine Receptor Antagonist So Far

[2] Constanze C Schmies, et al. ACS Med Chem Lett. Fluorescent Probes for Ecto-5'-nucleotidase (CD73)

[3] Sanjay Bhattarai, et al. J Med Chem. α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors

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Keywords: PSB-12379 supplier, inhibitors, activators

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