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PS432

Cat. No. M8759

All AbMole products are for research use only, cannot be used for human consumption.

PS432 Structure

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Quality Control & Documentation
Biological Activity

PS432 is an allosteric inhibitor of Protein Kinase C (PKC) that targets regulatory site (PIF-pocket) present in the kinase domain. PS432 potently inhibits non-small cell lung cancer cells proliferation and tumor growth without side effects in a mouse xenograft model.

Chemical Information
Molecular Weight 494.95
Formula C25H19ClN2O5S
CAS Number 2083630-26-4
Solubility (25°C) DMSO: 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jose M Arencibia, et al. An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms

[2] Georgia Arentz, et al. Increased Phospho-Keratin 8 Isoforms in Colorectal Tumors Associated with EGFR Pathway Activation and Reduced Apoptosis

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Keywords: PS432 supplier, inhibitors, activators

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