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Prucalopride is a selective, high affinity 5-HT4 receptor agonist with Ki of 2.5 nM and 8 nM for 5-HT4A and 5-HT4B receptor, respectively. Prucalopride has >150-fold higher affinity for 5-HT4 receptors than for other receptors. Prucalopride induces contractions in a concentration-dependent manner with pEC50 of 7.5. Prucalopride (4 mg) significantly reduced the need for straining versus placebo (p < 0.05). In vitro data indicate that prucalopride has a low interaction potential, and therapeutic concentrations of prucalopride are not expected to affect the CYP-mediated metabolism of co-medicated medicinal products.
| Molecular Weight | 367.87 |
| Formula | C18H26ClN3O3 |
| CAS Number | 179474-81-8 |
| Solubility (25°C) | DMSO 50 mg/mL Ethanol 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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