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PROTAC BTK degraders-5is a selective BTK degrader with a DC50 value of 7.0 nM in JeKo-1 cells.
| Molecular Weight | 958.52 |
| Formula | C52H57ClFN9O6 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Daniel Schaefer et al. Pharmaceuticals (Basel). Recent Advances in Covalent Drug Discovery
[3] Zi Liu et al. Mol Biomed. An overview of PROTACs: a promising drug discovery paradigm
[4] Tingting Yao et al. Int J Mol Sci. Recent Advances in PROTACs for Drug Targeted Protein Research
| Related BTK Products |
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| PCI-32765
PCI-32765 (Ibrutinib) is a potent, selective and orally bioavailable irreversible inhibitor of BTK with IC50 value of 0.46 nM. |
| Spebrutinib (AVL-292)
Spebrutinib (AVL-292) is an oral, potent and selective small molecule covalent inhibitor of Btk (IC50 < 0.5 nM). |
| CNX-774
CNX-774 is an irreversible, orally active, and highly selective BTK inhibitor with IC50 of <1 nM. |
| GDC-0834
GDC-0834 is a novel potent and selective BTK inhibitor with IC50 of 5.9 nM. |
| CGI1746
CGI1746 is a potent and highly selective small-molecule inhibitor of the Btk with IC50 of 1.9 nM. |
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