All AbMole products are for research use only, cannot be used for human consumption.
Prostratin is a pKC activator, with a Ki of 12.5 nM. Prostratin is also an NF-κB activator.
Prostratin inhibits growth and induces differentiation of AML cell lines. Prostratin enhances cytarabine-induced differentiation of AML cells.
Prostratin inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models.
| Molecular Weight | 390.47 |
| Formula | C22H30O6 |
| CAS Number | 60857-08-1 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage | 4°C, protect from light |
| Related PKC Products |
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| Enzastaurin
Enzastaurin inhibits PKCβ, PKCα, PKCγ and PKCε with IC50's of 0.006, 0.039, 0.083 and 0.110 µM, respectively. |
| Go 6983
Go 6983 is a fast acting, lipid soluble, broad spectrum protein kinase C inhibitor. |
| Staurosporine
Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. |
| Zoledronic acid
Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects. |
| Dequalinium Chloride
Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM. |
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