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Prosapogenin A

Cat. No. M10674

All AbMole products are for research use only, cannot be used for human consumption.

Prosapogenin A Structure
Synonym:

Progenin III; Polyphyllin E

Size Price Availability Quantity
1mg USD 40 In stock
5mg USD 99 In stock
10mg USD 164 In stock
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Quality Control & Documentation
Biological Activity

Prosapogenin A is a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis. Prosapogenin A (Polyphyllin E) is one of the important monomers of Chonglou extract, which has good anticancer effect. Prosapogenin A monomer showed a good in vitro antitumor effect on colon cancer cells. Compared with oxaliplatin, a commonly used anti-tumor compound, Prosapogenin A (Polyphyllin E) has strong anti-tumor properties on colon cancer cells and has the potential to become an effective anti-colon cancer compound.

Chemical Information
Molecular Weight 722.90
Formula C39H62O12
CAS Number 19057-67-1
Solubility (25°C) DMSO ≥ 80 mg/mL
Storage 2-8°C, protect from light, sealed
References

[1] Chengyu Yang, et al. Nat Prod Res. Conversion of Dioscorea zingiberensis saponins to prosapogenin A by enzymatic hydrolysis

[2] Jia Li, et al. Front Plant Sci. Identification and Characterization of a Trillin Rhamnosyltransferase From Dioscorea zingiberensis

[3] No authors listed. Nat Prod Res. Ginseng

[4] Tian-Xiao Wang, et al. Oncol Lett. Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis

[5] S W Pelletier, et al. Tetrahedron Lett. A prosapogenin from Polygala senega and Polygala tenuifolia

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Keywords: Prosapogenin A, Progenin III; Polyphyllin E supplier, Apoptosis, inhibitors, activators

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