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Propofol inhibited tumor size, cell viability and promoted cell apoptosis via inhibiting mTOR/p70S6K pathway mediated by HOTAIR in cervical cancer. In present study, we found propofol markedly decreased the HOTAIR expression of cervical cancer cells in a dose-dependent manner. In vitro experiments, we found HOTAIR overexpression promoted cervical carcinoma cells growth and inhibited cell apoptosis after the treatment of propofol.
| Cell Experiment | |
|---|---|
| Cell lines | Caski cells |
| Preparation method | 1 × 10^4 cells/well HeLa, CaSki and C33A cells were plated incubated in 96-well culture plates at 37℃ for 24 h, and then co-cultured with different concentrations (0 μg/ml, 1 μg/ml, 5 μg/ml and 10 μg/ml) of propofol for another 48 h. |
| Concentrations | 10 μg/ml |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6 mice |
| Formulation | soybean oil |
| Dosages | 50 mg/kg |
| Administration | i.p. |
| Molecular Weight | 178.27 |
| Formula | C12H18O |
| CAS Number | 2078-54-8 |
| Form | Melting point 18°C |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | 2-8°C, sealed |
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