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Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs. BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment.
Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Molecular Weight | 128.13 |
| Formula | C6H8O3 |
| CAS Number | 55683-37-9 |
| Form | Liquid (density 1.140 g/mL) |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage | Pure form -20°C |
| Related PROTAC Linker Products |
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| 6-Maleimidocaproic Acid
A sulfhydryl reactive heterobifunctional crosslinking reagent. Widely used probe for introducing maleimides groups into biomolecules. A probe for thiol groups in proteins. |
| 5-Ethynyl-2'-deoxyuridine
5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. |
| EGNHS
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent, it is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). |
| Ac4ManNAz
Ac4ManNAz is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
| L-Azidohomoalanine hydrochloride
L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. |
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